2077985-50-1

2077985-50-1 structure

Name: CXCR4 probe 1
Chemical Name: CXCR4 probe 1
CAS Number: 2077985-50-1
Molecular Formula: C₂₄H₃₀₁₈FN₅O₄S
Molecular Weight: 502.59
Catalog: Signaling Pathways GPCR/G Protein CXCR
Create Date: 2022-08-13 01:02:56
Modify Date: 2024-01-19 19:50:51
CXCR4 probe 1 (compound 5) is a potent and specific CXCR4-targeted PET tracer with an IC50 value of 6.9 nM against CXCR4-specific antagonist peptide, TN14003. CXCR4 probe 1 has potential to be used as CXCR4-specific imaging probe to diagnose and monitor the prognosis of inflammatory diseases, CXCR4-positive tumors, and metastatic cancers[1].

Name	CXCR4 probe 1

Description	CXCR4 probe 1 (compound 5) is a potent and specific CXCR4-targeted PET tracer with an IC50 value of 6.9 nM against CXCR4-specific antagonist peptide, TN14003. CXCR4 probe 1 has potential to be used as CXCR4-specific imaging probe to diagnose and monitor the prognosis of inflammatory diseases, CXCR4-positive tumors, and metastatic cancers[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> GPCR/G Protein >> CXCR Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> CXCR
Target	CXCR4
In Vivo	CXCR4 probe 1 displays preferential accumulation in lung metastatic tumors and specifically binds to CXCR4-positive stem cells in bone marrow[1].
References	[1]. Oum YH, et al. A benzenesulfonamide derivative as a novel PET radioligand for CXCR4. Bioorg Med Chem. 2020 Jan 15;28(2):115240.

Molecular Formula	C₂₄H₃₀₁₈FN₅O₄S
Molecular Weight	502.59