2490538-41-3
2490538-41-3 structure
- Name: FTase-IN-1
- Chemical Name: FTase-IN-1
- CAS Number: 2490538-41-3
- Molecular Formula: C23H16N2O2S
- Molecular Weight: 384.45
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Farnesyl Transferase
- Create Date: 2022-08-09 17:24:00
- Modify Date: 2024-01-09 23:26:07
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FTase-IN-1 (compound 17a) is a potent and specific inhibitor of fanesyl transferase (FTase) with an IC50 of 0.35 μM. FTase-IN-1 displays cytotoxicity potential and antitumor activity[1].
| Name | FTase-IN-1 |
|---|
| Description | FTase-IN-1 (compound 17a) is a potent and specific inhibitor of fanesyl transferase (FTase) with an IC50 of 0.35 μM. FTase-IN-1 displays cytotoxicity potential and antitumor activity[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 0.35 μM (fanesyl transferase)[1] |
| In Vitro | FTase-IN-1 (compound 17a) (10 μM, 48 h) is an inhibitors of farnesyl transferase (FTase) and inhibits NCI-60 cells proliferation in vitro[1]. FTase-IN-1 (10 μM, 48 h) arrests the cell growth of multiple cancer cell lines with GI50 range from 1.8 to 6.5 nM[1]. Cell Viability Assay[1] Cell Line: NCI-H522 (lung cancer), COLO-205 and HT29 (colon cancer), SF-539 (human glioblastoma), MDA-MB-435 (melanoma), OVCAR-3 (ovarian cancer) and A498 (renal cancer) Concentration: 10 μM Incubation Time: 48 hours Result: Inhibited cell growth and showed strong antitumor activity. |
| References |
| Molecular Formula | C23H16N2O2S |
|---|---|
| Molecular Weight | 384.45 |