2480283-75-6

2480283-75-6 structure

Name: hCAI/II-IN-2
Chemical Name: hCAI/II-IN-2
CAS Number: 2480283-75-6
Molecular Formula: C₁₂H₁₂N₄O₅S₂
Molecular Weight: 356.38
Catalog: Signaling Pathways Metabolic Enzyme/Protease Carbonic Anhydrase
Create Date: 2022-08-17 12:58:22
Modify Date: 2024-01-16 20:01:50
hCAI/II-IN-2 (compound 2b) is a potent dual hCA I/II inhibitor with Ki values of 40.97, 15.15 and 61.88 nM for hCA I, hCA II and hCA Ⅸ. hCAI/II-IN-2 possesses anti-hypoxic activity against acute mountain sickness (AMS) and low cellular activity[1].

Name	hCAI/II-IN-2

Description	hCAI/II-IN-2 (compound 2b) is a potent dual hCA I/II inhibitor with Ki values of 40.97, 15.15 and 61.88 nM for hCA I, hCA II and hCA Ⅸ. hCAI/II-IN-2 possesses anti-hypoxic activity against acute mountain sickness (AMS) and low cellular activity[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Metabolic Enzyme/Protease >> Carbonic Anhydrase
In Vitro	hCAI/II-IN-2 (compound 2b) (5-200 μM, 48 hours; HEK293T cells) has no obvious toxicity at HEK293T cells[1]. Cell Cytotoxicity Assay[1] Cell Line: Embryonic kidney (HEK293T) cells Concentration: 5, 25, 50, 100 and 200 μM Incubation Time: 48 hours Result: Had no apparent cytotoxicity.
In Vivo	Animal Model: Male BLAB/c mice[1] Dosage: 400 mg/kg Administration: Oral administration; 14 days. Result: Prolonged the survival time of mice by 21.7% compared with the blank control group.
References	[1]. Yang C, et al. N-Quinary heterocycle-4-sulphamoylbenzamides exert anti-hypoxic effects as dual inhibitors of carbonic anhydrases I/II. Bioorg Chem. 2020 Jul;100:103931.

Molecular Formula	C₁₂H₁₂N₄O₅S₂
Molecular Weight	356.38