2428389-67-5

2428389-67-5 structure

Name: hCAI/II-IN-5
Chemical Name: hCAI/II-IN-5
CAS Number: 2428389-67-5
Molecular Formula: C₂₁H₁₈Cl₂N₈O₄S₂
Molecular Weight: 581.45
Catalog: Signaling Pathways Metabolic Enzyme/Protease Carbonic Anhydrase
Create Date: 2022-08-03 09:16:54
Modify Date: 2024-01-09 14:31:58
hCAI/II-IN-5 (compound MZ8) is a potent hCA I and hCA II (human carbonic anhydrase isoenzymes I and II) inhibitor, with IC50 values of 37.88 and 45.23 nM, respectively. hCAI/II-IN-5 also shows inhibition profile against α-Glycosidase and AChE, with IC50 values of 48.98 and 420.14 nM, respectively. hCAI/II-IN-5 can be used for the research of many diseases such as diabetes, Alzheimer’s disease, heart failure, ulcer, and epilepsy[1].

Name	hCAI/II-IN-5

Description	hCAI/II-IN-5 (compound MZ8) is a potent hCA I and hCA II (human carbonic anhydrase isoenzymes I and II) inhibitor, with IC50 values of 37.88 and 45.23 nM, respectively. hCAI/II-IN-5 also shows inhibition profile against α-Glycosidase and AChE, with IC50 values of 48.98 and 420.14 nM, respectively. hCAI/II-IN-5 can be used for the research of many diseases such as diabetes, Alzheimer’s disease, heart failure, ulcer, and epilepsy[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Carbonic Anhydrase Research Areas >> Metabolic Disease Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> AChE
Target	IC50: 37.88 ± 0.9956 nM (hCA II), 45.23 ± 0.9684 nM (hCA I), 48.98 ± 0.9407 nM (α-GLY), 420.14 ± 0.9759 nM (AChE); KI: 40.35 ± 5.74 nM (hCA II), 50.04 ± 5.76 nM (α-GLY), 51.67 ± 4.76 nM (hCA I), 363.96 ± 32.87 nM (AChE)[1]
References	[1]. Lolak N, et al. Synthesis, characterization, inhibition effects, and molecular docking studies as acetylcholinesterase, α-glycosidase, and carbonic anhydrase inhibitors of novel benzenesulfonamides incorporating 1,3,5-triazine structural motifs. Bioorg Chem. 2020 Jul;100:103897.

Molecular Formula	C₂₁H₁₈Cl₂N₈O₄S₂
Molecular Weight	581.45