1809163-24-3

1809163-24-3 structure
1809163-24-3 structure
  • Name: HDAC-IN-43
  • Chemical Name: HDAC-IN-43
  • CAS Number: 1809163-24-3
  • Molecular Formula: C22H28N6O4
  • Molecular Weight: 440.50
  • Catalog: Signaling Pathways Cell Cycle/DNA Damage HDAC
  • Create Date: 2022-09-08 12:42:53
  • Modify Date: 2024-04-06 16:38:21
  • HDAC-IN-43 is a potent HDAC 1/3/6 inhibitor with IC50 values of 82, 45, and 24 nM, respectively. HDAC-IN-43 is a weak PI3K/mTOR inhibitors with IC50 values of 3.6 and 3.7 μM, respectively. HDAC-IN-43 shows broad anti-proliferative activity [1].

Name HDAC-IN-43
Description HDAC-IN-43 is a potent HDAC 1/3/6 inhibitor with IC50 values of 82, 45, and 24 nM, respectively. HDAC-IN-43 is a weak PI3K/mTOR inhibitors with IC50 values of 3.6 and 3.7 μM, respectively. HDAC-IN-43 shows broad anti-proliferative activity [1].
Related Catalog
Target

HDAC1:82 nM (IC50)

HDAC2:358 nM (IC50)

HDAC3:45 nM (IC50)

HDAC6:24 nM (IC50)

HDAC8:1441 nM (IC50)

HDAC10:182 nM (IC50)

HDAC11:9061 nM (IC50)

In Vitro HDAC-IN-43 demonstrats broad anti-cancer activities against 38 cancer cell lines at 72 hours [1]. Cell Viability Assay Cell Line: K562, MOLT4, MV4-11, Raji, Ramos, SU-DHL-6, HepG2, HuH-7, PLC/PRF/5, SK-HEP1, SNU-387, SNU-398, MCF7 and PC-2[1] Concentration: 0.22-1.42 μM Incubation Time: 72 h Result: showed anti-cancer activities, the IC50 values of K562, MOLT4, MV4-11, Raji, Ramos, SU-DHL-6, HepG2, HuH-7, PLC/PRF/5, SK-HEP1, SNU-387, SNU-398, MCF7 and PC-2 are 0.22-1.42 μM[1].
References

[1]. Dizhong Chen, et al. Synthesis and biological evaluation of 6-phenylpurine linked hydroxamates as novel histone deacetylase inhibitors. Bioorg Chem. 2020 May;98:103724.

Molecular Formula C22H28N6O4
Molecular Weight 440.50
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