HDAC-IN-43
Modify Date: 2024-04-06 16:38:21
HDAC-IN-43 structure
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Common Name | HDAC-IN-43 | ||
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| CAS Number | 1809163-24-3 | Molecular Weight | 440.50 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H28N6O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of HDAC-IN-43HDAC-IN-43 is a potent HDAC 1/3/6 inhibitor with IC50 values of 82, 45, and 24 nM, respectively. HDAC-IN-43 is a weak PI3K/mTOR inhibitors with IC50 values of 3.6 and 3.7 μM, respectively. HDAC-IN-43 shows broad anti-proliferative activity [1]. |
| Name | HDAC-IN-43 |
|---|
| Description | HDAC-IN-43 is a potent HDAC 1/3/6 inhibitor with IC50 values of 82, 45, and 24 nM, respectively. HDAC-IN-43 is a weak PI3K/mTOR inhibitors with IC50 values of 3.6 and 3.7 μM, respectively. HDAC-IN-43 shows broad anti-proliferative activity [1]. |
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| Related Catalog | |
| Target |
HDAC1:82 nM (IC50) HDAC2:358 nM (IC50) HDAC3:45 nM (IC50) HDAC6:24 nM (IC50) HDAC8:1441 nM (IC50) HDAC10:182 nM (IC50) HDAC11:9061 nM (IC50) |
| In Vitro | HDAC-IN-43 demonstrats broad anti-cancer activities against 38 cancer cell lines at 72 hours [1]. Cell Viability Assay Cell Line: K562, MOLT4, MV4-11, Raji, Ramos, SU-DHL-6, HepG2, HuH-7, PLC/PRF/5, SK-HEP1, SNU-387, SNU-398, MCF7 and PC-2[1] Concentration: 0.22-1.42 μM Incubation Time: 72 h Result: showed anti-cancer activities, the IC50 values of K562, MOLT4, MV4-11, Raji, Ramos, SU-DHL-6, HepG2, HuH-7, PLC/PRF/5, SK-HEP1, SNU-387, SNU-398, MCF7 and PC-2 are 0.22-1.42 μM[1]. |
| References |
| Molecular Formula | C22H28N6O4 |
|---|---|
| Molecular Weight | 440.50 |