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2414921-46-1

2414921-46-1 structure

2414921-46-1 structure

Name: HDAC-IN-44
Chemical Name: HDAC-IN-44
CAS Number: 2414921-46-1
Molecular Formula: C₂₆H₂₇BrN₄O₄
Molecular Weight: 539.42
Catalog: Signaling Pathways Cell Cycle/DNA Damage HDAC
Create Date: 2022-08-05 07:23:01
Modify Date: 2025-08-25 19:00:30
HDAC-IN-44 is a HDAC inhibitor with the IC50 value of 61.2 nM. HDAC-IN-44 shows high anticancer activity towards multiple cancer cell lines[1].

Name	HDAC-IN-44

Description	HDAC-IN-44 is a HDAC inhibitor with the IC50 value of 61.2 nM. HDAC-IN-44 shows high anticancer activity towards multiple cancer cell lines[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> Epigenetics >> HDAC
In Vitro	HDAC-IN-44 (20 µg/mL; 24 h) treatment shows inhibitory effects on acute lymphoblastic leukemia (Molt 4 cells), T-cell lymphoblastic lymphoma (Sup-T1 cells), chronic myelogenous leukemia (K562 cells), gastric adenocarcinoma (AGS), prostate cancer (PC3 and LNCaP cells) and breast cancer (T47D cells) [1]. Cell Viability Assay Cell Line: Molt 4, Sup-T1, K562, AGS, PC-3, LNCaP, T47D cells[1] Concentration: 20 µg/mL Incubation Time: 24 hours Result: Exhibited IC50 values of 11, 9.1, 16.3, 7.1, 13.4, 32.7 and 9.2 μM in Molt 4, Sup-T1, K562, AGS, PC-3, LNCaP, T47D cells, respectively[1].
References	[1]. Ahmed K ElHady et al. Extending the use of tadalafil scaffold: Development of novel selective phosphodiesterase 5 inhibitors and histone deacetylase inhibitors. Bioorg Chem. 2020 May;98:103742.

Molecular Formula	C₂₆H₂₇BrN₄O₄
Molecular Weight	539.42

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