1995132-67-6

1995132-67-6 structure

Name: HSP90-IN-14
Chemical Name: HSP90-IN-14
CAS Number: 1995132-67-6
Molecular Formula: C₁₄H₈Cl₂N₄O₄S
Molecular Weight: 399.21
Catalog: Signaling Pathways Anti-infection Influenza Virus
Create Date: 2022-08-12 09:13:42
Modify Date: 2024-01-17 17:58:25
HSP90-IN-14 (compound 4) is a potent Hsp90 (heat shock protein 90) inhibitor, with a Kd of 0.26 μM. HSP90-IN-14 shows anti-influenza virus activity in MDCK cells, with EC50 values of 2.6, 3.9, and 17 μM for influenza A/H3N2, A/H1N1, and B, respectively[1].

Name	HSP90-IN-14

Description	HSP90-IN-14 (compound 4) is a potent Hsp90 (heat shock protein 90) inhibitor, with a Kd of 0.26 μM. HSP90-IN-14 shows anti-influenza virus activity in MDCK cells, with EC50 values of 2.6, 3.9, and 17 μM for influenza A/H3N2, A/H1N1, and B, respectively[1].
Related Catalog	Signaling Pathways >> Anti-infection >> Influenza Virus Signaling Pathways >> Metabolic Enzyme/Protease >> HSP Research Areas >> Infection Signaling Pathways >> Cell Cycle/DNA Damage >> HSP
Target	HSP90β:0.26 ± 0.0 μM (Kd)
In Vitro	HSP90-IN-14 (compound 4) (50 µM) inhibits influenza virus-induced cytopathic effect at non-toxic concentrations[1].
References	[1]. Lamut A, et al. Anti-influenza virus activity of benzo[d]thiazoles that target heat shock protein 90. Bioorg Chem. 2020 May;98:103733.

Molecular Formula	C₁₄H₈Cl₂N₄O₄S
Molecular Weight	399.21