Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Palmitic acid
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

2697112-32-4

2697112-32-4 structure

2697112-32-4 structure

Name: JNJ-4355
Chemical Name: JNJ-4355
CAS Number: 2697112-32-4
Molecular Formula: C₄₀H₄₃ClFN₅O₅S
Molecular Weight: 760.32
Catalog: Signaling Pathways Apoptosis Bcl-2 Family
Create Date: 2022-08-16 15:49:54
Modify Date: 2025-08-25 09:53:28
JNJ-4355 is a highly potent MCL-1 (myeloid cell leukemia-1) inhibitor, with KI of 18 pM. JNJ-4355 shows antitumor activity[1][2].

Name	JNJ-4355

Description	JNJ-4355 is a highly potent MCL-1 (myeloid cell leukemia-1) inhibitor, with KI of 18 pM. JNJ-4355 shows antitumor activity[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Bcl-2 Family Research Areas >> Cancer
Target	Mcl-1:18 pM (Ki)
In Vitro	JNJ-4355 shows promising in vitro potency data in cancer cell lines and AML patient-derived samples[2].
In Vivo	JNJ-4355 (IV , single) shows complete tumor regression in a mouse MOLP8 (multiple myeloma) xenograft[2].
References	[1]. Matthieu Jouffroy, et al. Synthesis of Atropisomeric Biaryls via Chiral Suzuki–Miyaura/Enzymatic Kinetic Resolution. ACS Catal. 2022, 12, 8380–8385. [2]. Frederik J. Rombouts, et al. Abstract 2133: In pursuit of MCL-1 inhibitors with improved therapeutic window for the treatment of hematological malignancies: Discovery of JNJ-4355. Cancer Res (2022) 82 (12_Supplement): 2133.

Molecular Formula	C₄₀H₄₃ClFN₅O₅S
Molecular Weight	760.32

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.