JNJ-4355

Modify Date: 2024-01-17 16:44:07

JNJ-4355 Structure
JNJ-4355 structure
Common Name JNJ-4355
CAS Number 2697112-32-4 Molecular Weight 760.32
Density N/A Boiling Point N/A
Molecular Formula C40H43ClFN5O5S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of JNJ-4355


JNJ-4355 is a highly potent MCL-1 (myeloid cell leukemia-1) inhibitor, with KI of 18 pM. JNJ-4355 shows antitumor activity[1][2].

 Names

Name JNJ-4355

 JNJ-4355 Biological Activity

Description JNJ-4355 is a highly potent MCL-1 (myeloid cell leukemia-1) inhibitor, with KI of 18 pM. JNJ-4355 shows antitumor activity[1][2].
Related Catalog
Target

Mcl-1:18 pM (Ki)

In Vitro JNJ-4355 shows promising in vitro potency data in cancer cell lines and AML patient-derived samples[2].
In Vivo JNJ-4355 (IV , single) shows complete tumor regression in a mouse MOLP8 (multiple myeloma) xenograft[2].
References

[1]. Matthieu Jouffroy, et al. Synthesis of Atropisomeric Biaryls via Chiral Suzuki–Miyaura/Enzymatic Kinetic Resolution. ACS Catal. 2022, 12, 8380–8385.

[2]. Frederik J. Rombouts, et al. Abstract 2133: In pursuit of MCL-1 inhibitors with improved therapeutic window for the treatment of hematological malignancies: Discovery of JNJ-4355. Cancer Res (2022) 82 (12_Supplement): 2133.

 Chemical & Physical Properties

Molecular Formula C40H43ClFN5O5S
Molecular Weight 760.32