2413564-66-4

2413564-66-4 structure

Name: PDE4-IN-10
Chemical Name: PDE4-IN-10
CAS Number: 2413564-66-4
Molecular Formula: C₁₈H₁₃N
Molecular Weight: 243.30
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphodiesterase (PDE)
Create Date: 2022-08-17 00:38:16
Modify Date: 2024-01-16 10:50:04
PDE4-IN-10 (compound 7a) is a potent PDE4 inhibitor, with an IC50 of 7.01 μM for PDE4B. PDE4-IN-10 shows selectivity, microsomal stability, inhibition of TNF-α and no major toxicities in vitro[1].

Name	PDE4-IN-10

Description	PDE4-IN-10 (compound 7a) is a potent PDE4 inhibitor, with an IC50 of 7.01 μM for PDE4B. PDE4-IN-10 shows selectivity, microsomal stability, inhibition of TNF-α and no major toxicities in vitro[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Research Areas >> Inflammation/Immunology
Target	PDE4B:7.01 ± 1.0 μM (IC50) PDE4D TNF-α
In Vitro	PDE4-IN-10 (compound 7a) shows 64.56% inhibition at 10 µM against PDE4B, 54% inhibition at 30 µM but 17% inhibition at 10 µM against PDE4D, indicating its selectivity (~3.8 fold) towards PDE4B over PDE4D[1].
References	[1]. Bta B, et al. Synthesis of 11,12-dihydro benzo[c]phenanthridines via a Pd-catalyzed unusual construction of isocoumarin ring/FeCl3-mediated intramolecular arene-allyl cyclization: First identification of a benzo[c]phenanthridine based PDE4 inhibitor - ScienceDirect. Bioorganic Chemistry. April 2020;97:103691.

Molecular Formula	C₁₈H₁₃N
Molecular Weight	243.30