2411389-67-6

2411389-67-6 structure

Name: PROTAC CYP1B1 degrader-1
Chemical Name: PROTAC CYP1B1 degrader-1
CAS Number: 2411389-67-6
Molecular Formula: C₄₃H₃₉N₅O₁₀
Molecular Weight: 785.80
Catalog: Signaling Pathways Metabolic Enzyme/Protease Cytochrome P450
Create Date: 2022-08-17 10:10:36
Modify Date: 2024-01-12 23:16:22
PROTAC CYP1B1 degrader-1 (Compound 6C), a α-naphthoflavone chimera derivative, is able to eliminate cytochrome P450 (CYP)1B1-mediated drug resistance via targeted CYP1B1 degradation, with IC50s of 95.1 and 9838.6 nM for CYP1B1 and CYP1A2, respectively. PROTAC CYP1B1 degrader-1 can be used for the research of CYP1B1-overexpressing prostate cancer[1].

Name	PROTAC CYP1B1 degrader-1

Description	PROTAC CYP1B1 degrader-1 (Compound 6C), a α-naphthoflavone chimera derivative, is able to eliminate cytochrome P450 (CYP)1B1-mediated drug resistance via targeted CYP1B1 degradation, with IC50s of 95.1 and 9838.6 nM for CYP1B1 and CYP1A2, respectively. PROTAC CYP1B1 degrader-1 can be used for the research of CYP1B1-overexpressing prostate cancer[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450 Signaling Pathways >> PROTAC >> PROTAC
References	[1]. Li Zhou, et al. Design and synthesis of α-naphthoflavone chimera derivatives able to eliminate cytochrome P450 (CYP)1B1-mediated drug resistance via targeted CYP1B1 degradation. Eur J Med Chem. 2020 Mar 1;189:112028.

Molecular Formula	C₄₃H₃₉N₅O₁₀
Molecular Weight	785.80