PROTAC CYP1B1 degrader-1

Modify Date: 2024-01-12 23:16:22

PROTAC CYP1B1 degrader-1 structure	Common Name	PROTAC CYP1B1 degrader-1
	CAS Number	2411389-67-6	Molecular Weight	785.80
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₄₃H₃₉N₅O₁₀	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of PROTAC CYP1B1 degrader-1

PROTAC CYP1B1 degrader-1 (Compound 6C), a α-naphthoflavone chimera derivative, is able to eliminate cytochrome P450 (CYP)1B1-mediated drug resistance via targeted CYP1B1 degradation, with IC50s of 95.1 and 9838.6 nM for CYP1B1 and CYP1A2, respectively. PROTAC CYP1B1 degrader-1 can be used for the research of CYP1B1-overexpressing prostate cancer[1].

Name	PROTAC CYP1B1 degrader-1

Description	PROTAC CYP1B1 degrader-1 (Compound 6C), a α-naphthoflavone chimera derivative, is able to eliminate cytochrome P450 (CYP)1B1-mediated drug resistance via targeted CYP1B1 degradation, with IC50s of 95.1 and 9838.6 nM for CYP1B1 and CYP1A2, respectively. PROTAC CYP1B1 degrader-1 can be used for the research of CYP1B1-overexpressing prostate cancer[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450 Signaling Pathways >> PROTAC >> PROTAC
References	[1]. Li Zhou, et al. Design and synthesis of α-naphthoflavone chimera derivatives able to eliminate cytochrome P450 (CYP)1B1-mediated drug resistance via targeted CYP1B1 degradation. Eur J Med Chem. 2020 Mar 1;189:112028.

Molecular Formula	C₄₃H₃₉N₅O₁₀
Molecular Weight	785.80

PROTAC CYP1B1 degrader-1

Use of PROTAC CYP1B1 degrader-1

Names

PROTAC CYP1B1 degrader-1 Biological Activity

Chemical & Physical Properties