2260670-12-8

2260670-12-8 structure

Name: Psychosine-d5
Chemical Name: Psychosine-d5
CAS Number: 2260670-12-8
Molecular Formula: C₂₄H₄₂D₅NO₇
Molecular Weight: 466.66
Catalog: Signaling Pathways Epigenetics PKC
Create Date: 2022-08-16 16:28:56
Modify Date: 2024-09-13 20:39:51
Psychosine-d5 is deuterium labeled Psychosine. Psychosine, a substrate of the galactocerebrosidase (GALC) enzyme, is a potential biomarker for Krabbe disease. Psychosine is a highly cytotoxic lipid, capable of inducing cell death in a wide variety of cell.

Name	Psychosine-d5

Description	Psychosine-d5 is deuterium labeled Psychosine. Psychosine, a substrate of the galactocerebrosidase (GALC) enzyme, is a potential biomarker for Krabbe disease. Psychosine is a highly cytotoxic lipid, capable of inducing cell death in a wide variety of cell.
Related Catalog	Signaling Pathways >> Epigenetics >> PKC Research Areas >> Cancer Research Areas >> Neurological Disease Signaling Pathways >> TGF-beta/Smad >> PKC
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[3].
References	[1]. M L Escolar, et al. Psychosine, a marker of Krabbe phenotype and treatment effect. Mol Genet Metab. 2017 Jul;121(3):271-278. [2]. Jacqueline A Hawkins-Salsbury,et al.Psychosine, the cytotoxic sphingolipid that accumulates in globoid cell leukodystrophy, alters membrane architecture. J Lipid Res.2013 Dec;54(12):3303-11. [3]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223.

Molecular Formula	C₂₄H₄₂D₅NO₇
Molecular Weight	466.66