1126365-66-9

1126365-66-9 structure

1126365-66-9 structure

Name: SMO-IN-1
Chemical Name: SMO-IN-1
CAS Number: 1126365-66-9
Molecular Formula: C₂₄H₂₂N₄O₂
Molecular Weight: 398.46
Catalog: Signaling Pathways Stem Cell/Wnt Smo
Create Date: 2022-08-02 11:10:11
Modify Date: 2024-01-09 13:05:32
SMO-IN-1 (Compound 15) is an orally active Smoothened (SMO) inhibitor with an EC50 of 89 nM against sonic Hh protein (shh)[1].

Name	SMO-IN-1

Description	SMO-IN-1 (Compound 15) is an orally active Smoothened (SMO) inhibitor with an EC50 of 89 nM against sonic Hh protein (shh)[1].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> Smo Research Areas >> Cancer
References	[1]. Yang B, et al. Heteroarylamide smoothened inhibitors: Discovery of N-[2,4-dimethyl-5-(1-methylimidazol-4-yl)phenyl]-4-(2-pyridylmethoxy)benzamide (AZD8542) and N-[5-(1H-imidazol-2-yl)-2,4-dimethyl-phenyl]-4-(2- pyridylmethoxy)benzamide (AZD7254). Bioorg Med Chem. 2020 Jan 15;28(2):115227.

Molecular Formula	C₂₄H₂₂N₄O₂
Molecular Weight	398.46