2636072-62-1

2636072-62-1 structure

Name: SS47
Chemical Name: SS47
CAS Number: 2636072-62-1
Molecular Formula: C₄₉H₅₆N₆O₁₂S
Molecular Weight: 953.07
Catalog: Signaling Pathways MAPK/ERK Pathway MAP4K
Create Date: 2022-08-16 18:34:02
Modify Date: 2024-01-23 11:34:04
SS47, a PROTAC-based HPK1 degrader, exerts proteasome-mediated HPK1 degradation. The degradation of HPK1 via SS47 also significantly enhances the in vivo antitumor efficacy of BCMA CAR-T cell treatment. HPK1, an immunosuppressive regulatory kinase, is a promising target for cancer immunotherapies[1].

Name	SS47

Description	SS47, a PROTAC-based HPK1 degrader, exerts proteasome-mediated HPK1 degradation. The degradation of HPK1 via SS47 also significantly enhances the in vivo antitumor efficacy of BCMA CAR-T cell treatment. HPK1, an immunosuppressive regulatory kinase, is a promising target for cancer immunotherapies[1].
Related Catalog	Signaling Pathways >> MAPK/ERK Pathway >> MAP4K Research Areas >> Cancer Research Areas >> Inflammation/Immunology Signaling Pathways >> PROTAC >> PROTAC
References	[1]. Jingwen Si, et al. Hematopoietic Progenitor Kinase1 (HPK1) Mediates T Cell Dysfunction and Is a Druggable Target for T Cell-Based Immunotherapies. Cancer Cell. 2020 Oct 12;38(4):551-566.e11.

Molecular Formula	C₄₉H₅₆N₆O₁₂S
Molecular Weight	953.07