SS47
Modify Date: 2025-08-26 22:14:00
SS47 structure
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Common Name | SS47 | ||
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| CAS Number | 2636072-62-1 | Molecular Weight | 953.07 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C49H56N6O12S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SS47SS47, a PROTAC-based HPK1 degrader, exerts proteasome-mediated HPK1 degradation. The degradation of HPK1 via SS47 also significantly enhances the in vivo antitumor efficacy of BCMA CAR-T cell treatment. HPK1, an immunosuppressive regulatory kinase, is a promising target for cancer immunotherapies[1]. |
| Name | SS47 |
|---|
| Description | SS47, a PROTAC-based HPK1 degrader, exerts proteasome-mediated HPK1 degradation. The degradation of HPK1 via SS47 also significantly enhances the in vivo antitumor efficacy of BCMA CAR-T cell treatment. HPK1, an immunosuppressive regulatory kinase, is a promising target for cancer immunotherapies[1]. |
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| Related Catalog | |
| References |
| Molecular Formula | C49H56N6O12S |
|---|---|
| Molecular Weight | 953.07 |
| InChIKey | LUUCVCRHWBVGNN-UHFFFAOYSA-N |
| SMILES | CC(C)(O)C#Cc1cccc(COc2cc(-c3cnc(C4CCN(C(=O)CCOCCOCCOCCOCCOc5cccc6c5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)s3)cnc2N)c1 |