859142-95-3

859142-95-3 structure

Name: TDP1 Inhibitor-2
Chemical Name: TDP1 Inhibitor-2
CAS Number: 859142-95-3
Molecular Formula: C₂₅H₁₄Cl₂O₅
Molecular Weight: 465.28
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphodiesterase (PDE)
Create Date: 2022-08-06 17:04:17
Modify Date: 2024-01-31 09:45:49
TDP1 Inhibitor-2 (compound 5) is a potent inhibitor for TDP1 (tyrosyl-DNA phosphodiesterase 1), with an IC50 of 99 nM. TDP1 Inhibitor-2 also can inhibit SCAN1 (spinocerebellar ataxia syndrome with axonal neuropathy), with an IC50 of 3.5 μM[1].

Name	TDP1 Inhibitor-2

Description	TDP1 Inhibitor-2 (compound 5) is a potent inhibitor for TDP1 (tyrosyl-DNA phosphodiesterase 1), with an IC50 of 99 nM. TDP1 Inhibitor-2 also can inhibit SCAN1 (spinocerebellar ataxia syndrome with axonal neuropathy), with an IC50 of 3.5 μM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Research Areas >> Neurological Disease
Target	IC50: 0.099 ± 0.044 μM (TDP1), 3.5 ± 2.3 μM (SCAN1)[1]
In Vitro	TDP1 Inhibitor-2 (compound 5) shows potent anti-TDP1 activity, low cytotoxicity and synergism with topotecan, an established Top1 anticancer agent[1].
References	[1]. Mamontova EM, et al. Identification of novel inhibitors for the tyrosyl-DNA-phosphodiesterase 1 (Tdp1) mutant SCAN1 using virtual screening. Bioorg Med Chem. 2020 Jan 1;28(1):115234.

Molecular Formula	C₂₅H₁₄Cl₂O₅
Molecular Weight	465.28