2588211-50-9

2588211-50-9 structure

Name: Topoisomerase I inhibitor 3
Chemical Name: Topoisomerase I inhibitor 3
CAS Number: 2588211-50-9
Molecular Formula: C₁₈H₁₄FNO₃
Molecular Weight: 311.31
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2022-08-09 09:12:48
Modify Date: 2024-01-08 19:19:26
Topoisomerase I inhibitor 3 (Compound ZML-14) is a topoisomerase I inhibitor and can interact with topoisomerase I-DNA complex. Topoisomerase I inhibitor 3 induces HepG2 cell apoptosis and arrests cell cycle at G2/M phase[1].

Name	Topoisomerase I inhibitor 3

Description	Topoisomerase I inhibitor 3 (Compound ZML-14) is a topoisomerase I inhibitor and can interact with topoisomerase I-DNA complex. Topoisomerase I inhibitor 3 induces HepG2 cell apoptosis and arrests cell cycle at G2/M phase[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase
Target	Topoisomerase I
In Vitro	Topoisomerase I inhibitor 3 (Compound ZML-14) shows cytotoxicity with IC50 values of 1.94 ± 0.09, 10.32 ± 0.39, 13.1 ± 0.96, 40.69 ± 5.36, 28.11 ± 2.50, >100 and 37.42 ± 2.05 μM against HepG2, A2780, HeLa, HCT116, SW1990, MCF7 and L-02 cells, respectively[1].
References	[1]. Zhou Y, et al. Design and synthesis of Aza-boeravinone derivatives as potential novel topoisomerase I inhibitors. Bioorg Chem. 2022 May;122:105747.

Molecular Formula	C₁₈H₁₄FNO₃
Molecular Weight	311.31