Topoisomerase I inhibitor 3

Modify Date: 2024-01-08 19:19:26

Topoisomerase I inhibitor 3 structure	Common Name	Topoisomerase I inhibitor 3
	CAS Number	2588211-50-9	Molecular Weight	311.31
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₈H₁₄FNO₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Topoisomerase I inhibitor 3

Topoisomerase I inhibitor 3 (Compound ZML-14) is a topoisomerase I inhibitor and can interact with topoisomerase I-DNA complex. Topoisomerase I inhibitor 3 induces HepG2 cell apoptosis and arrests cell cycle at G2/M phase[1].

Name	Topoisomerase I inhibitor 3

Description	Topoisomerase I inhibitor 3 (Compound ZML-14) is a topoisomerase I inhibitor and can interact with topoisomerase I-DNA complex. Topoisomerase I inhibitor 3 induces HepG2 cell apoptosis and arrests cell cycle at G2/M phase[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase
Target	Topoisomerase I
In Vitro	Topoisomerase I inhibitor 3 (Compound ZML-14) shows cytotoxicity with IC50 values of 1.94 ± 0.09, 10.32 ± 0.39, 13.1 ± 0.96, 40.69 ± 5.36, 28.11 ± 2.50, >100 and 37.42 ± 2.05 μM against HepG2, A2780, HeLa, HCT116, SW1990, MCF7 and L-02 cells, respectively[1].
References	[1]. Zhou Y, et al. Design and synthesis of Aza-boeravinone derivatives as potential novel topoisomerase I inhibitors. Bioorg Chem. 2022 May;122:105747.

Molecular Formula	C₁₈H₁₄FNO₃
Molecular Weight	311.31

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Topoisomerase I inhibitor 3

Use of Topoisomerase I inhibitor 3

Names

Topoisomerase I inhibitor 3 Biological Activity

Chemical & Physical Properties

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