2476559-00-7

2476559-00-7 structure

Name: Topoisomerase II inhibitor 11
Chemical Name: Topoisomerase II inhibitor 11
CAS Number: 2476559-00-7
Molecular Formula: C₂₇H₂₁BrCl₂N₂O₂S
Molecular Weight: 588.34
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2022-08-12 10:47:22
Modify Date: 2024-01-17 17:46:24
Topoisomerase II inhibitor 11 (compound 3d) is a potent Topoisomerase II inhibitor, with an IC50 of 2.89 μM. Topoisomerase II inhibitor 11 shows 92.46% inhibition on renal cancer cell line A498 with an IC50 of 3.5 μM. Topoisomerase II inhibitor 11 causes cell cycle arrest at the G2/M phase leading to cell proliferation inhibition and pro-apoptotic activity[1].

Name	Topoisomerase II inhibitor 11

Description	Topoisomerase II inhibitor 11 (compound 3d) is a potent Topoisomerase II inhibitor, with an IC50 of 2.89 μM. Topoisomerase II inhibitor 11 shows 92.46% inhibition on renal cancer cell line A498 with an IC50 of 3.5 μM. Topoisomerase II inhibitor 11 causes cell cycle arrest at the G2/M phase leading to cell proliferation inhibition and pro-apoptotic activity[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase
Target	Topoisomerase II:2.89 μM (IC50)
References	[1]. Nemr MTM, et al. New fused pyrimidine derivatives with anticancer activity: Synthesis, topoisomerase II inhibition, apoptotic inducing activity and molecular modeling study. Bioorg Chem. 2020 Oct;103:104134.

Molecular Formula	C₂₇H₂₁BrCl₂N₂O₂S
Molecular Weight	588.34