Topoisomerase II inhibitor 11

Modify Date: 2025-08-27 15:09:54

Topoisomerase II inhibitor 11 structure	Common Name	Topoisomerase II inhibitor 11
	CAS Number	2476559-00-7	Molecular Weight	588.34
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₇H₂₁BrCl₂N₂O₂S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Topoisomerase II inhibitor 11

Topoisomerase II inhibitor 11 (compound 3d) is a potent Topoisomerase II inhibitor, with an IC50 of 2.89 μM. Topoisomerase II inhibitor 11 shows 92.46% inhibition on renal cancer cell line A498 with an IC50 of 3.5 μM. Topoisomerase II inhibitor 11 causes cell cycle arrest at the G2/M phase leading to cell proliferation inhibition and pro-apoptotic activity[1].

Name	Topoisomerase II inhibitor 11

Description	Topoisomerase II inhibitor 11 (compound 3d) is a potent Topoisomerase II inhibitor, with an IC50 of 2.89 μM. Topoisomerase II inhibitor 11 shows 92.46% inhibition on renal cancer cell line A498 with an IC50 of 3.5 μM. Topoisomerase II inhibitor 11 causes cell cycle arrest at the G2/M phase leading to cell proliferation inhibition and pro-apoptotic activity[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase
Target	Topoisomerase II:2.89 μM (IC50)
References	[1]. Nemr MTM, et al. New fused pyrimidine derivatives with anticancer activity: Synthesis, topoisomerase II inhibition, apoptotic inducing activity and molecular modeling study. Bioorg Chem. 2020 Oct;103:104134.

Molecular Formula	C₂₇H₂₁BrCl₂N₂O₂S
Molecular Weight	588.34

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Topoisomerase II inhibitor 11

Use of Topoisomerase II inhibitor 11

Names

Topoisomerase II inhibitor 11 Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.