2538528-11-7

2538528-11-7 structure

2538528-11-7 structure

Name: Topoisomerase IIα-IN-3
Chemical Name: Topoisomerase IIα-IN-3
CAS Number: 2538528-11-7
Molecular Formula: C₂₉H₂₀N₆O₂S
Molecular Weight: 516.57
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2022-08-05 16:43:50
Modify Date: 2024-01-08 10:00:24
Topoisomerase IIα-IN-3 (Compound 12c) is a DNA intercalative topoisomerase-IIα inhibitor. Topoisomerase IIα-IN-3 arrests cell cycle at the G0/G1 phase and induces apoptosis[1].

Name	Topoisomerase IIα-IN-3

Description	Topoisomerase IIα-IN-3 (Compound 12c) is a DNA intercalative topoisomerase-IIα inhibitor. Topoisomerase IIα-IN-3 arrests cell cycle at the G0/G1 phase and induces apoptosis[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase
Target	topoisomerase II alpha
In Vitro	Topoisomerase IIα-IN-3 (Compound 12c) shows cytotoxic potential with IC50 values of 2.82 ± 0.10, 3.28 ± 0.43, 4.09 ± 0.59, 4.78 ± 1.29, 3.83 ± 0.9,4 3.18 ± 0.49 and 71.25 ± 7.95 μM against A549, MDA-MB-231, BT-474, HCT-116, HL-60, THP-1 and BEAS-2B cells, respectively[1].
References	[1]. Tokala R, et al. Design and synthesis of thiadiazolo-carboxamide bridged β-carboline-indole hybrids: DNA intercalative topo-IIα inhibition with promising antiproliferative activity. Bioorg Chem. 2020 Dec;105:104357.

Molecular Formula	C₂₉H₂₀N₆O₂S
Molecular Weight	516.57