Topoisomerase IIα-IN-3
Modify Date: 2025-09-21 12:15:27
Topoisomerase IIα-IN-3 structure
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Common Name | Topoisomerase IIα-IN-3 | ||
|---|---|---|---|---|
| CAS Number | 2538528-11-7 | Molecular Weight | 516.57 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C29H20N6O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Topoisomerase IIα-IN-3Topoisomerase IIα-IN-3 (Compound 12c) is a DNA intercalative topoisomerase-IIα inhibitor. Topoisomerase IIα-IN-3 arrests cell cycle at the G0/G1 phase and induces apoptosis[1]. |
| Name | Topoisomerase IIα-IN-3 |
|---|
| Description | Topoisomerase IIα-IN-3 (Compound 12c) is a DNA intercalative topoisomerase-IIα inhibitor. Topoisomerase IIα-IN-3 arrests cell cycle at the G0/G1 phase and induces apoptosis[1]. |
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| Related Catalog | |
| Target |
topoisomerase II alpha |
| In Vitro | Topoisomerase IIα-IN-3 (Compound 12c) shows cytotoxic potential with IC50 values of 2.82 ± 0.10, 3.28 ± 0.43, 4.09 ± 0.59, 4.78 ± 1.29, 3.83 ± 0.9,4 3.18 ± 0.49 and 71.25 ± 7.95 μM against A549, MDA-MB-231, BT-474, HCT-116, HL-60, THP-1 and BEAS-2B cells, respectively[1]. |
| References |
| Molecular Formula | C29H20N6O2S |
|---|---|
| Molecular Weight | 516.57 |
| InChIKey | LLQVYDJGSVIJDS-UHFFFAOYSA-N |
| SMILES | COc1ccc(-c2nc(C(=O)Nc3nnc(-c4cc5ccccc5[nH]4)s3)cc3c2[nH]c2ccccc23)cc1 |