1044663-62-8

1044663-62-8 structure

Name: Topotecan hydrochloride hydrate
Chemical Name: Topotecan hydrochloride hydrate
CAS Number: 1044663-62-8
Molecular Formula: C₂₃H₂₆ClN₃O₆
Molecular Weight: 475.92
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2022-08-15 13:44:07
Modify Date: 2024-01-11 20:21:03
Topotecan hydrochloride hydrate is an orally active and potent Topoisomerase I inhibitor. Topotecan hydrochloride hydrate induces cell cycle arrest in G0/G1 and S phases and promotes apoptosis. Topotecan hydrochloride hydrate shows anticancer activity[1].

Name	Topotecan hydrochloride hydrate

Description	Topotecan hydrochloride hydrate is an orally active and potent Topoisomerase I inhibitor. Topotecan hydrochloride hydrate induces cell cycle arrest in G0/G1 and S phases and promotes apoptosis. Topotecan hydrochloride hydrate shows anticancer activity[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase Signaling Pathways >> Autophagy >> Autophagy
Target	Topoisomerase I
In Vitro	Topotecan hydrochloride hydrate obviously inhibits proliferation of human glioma cells and glioma stem cells (GSCs) in a dose- and time-dependent manner[1]. Topotecan hydrochloride hydrate (0-40 μM) obviously inhibits the cell viability compared with the control groups, in a dose-dependent manner[1]. Topotecan hydrochloride hydrate shows anti-proliferation activity against U251, U87, GSCs-U251 and GSCs-U87 cells, with IC50 values of 2.73±0.25, 2.95±0.23, 5.46±0.41, and 5.95±0.24 μM, respectively[1].
In Vivo	Topotecan hydrochloride hydrate (0.5, 1.0, and 1.5 mg/kg; Orally, daily) causes greater reduction in microvascular density in an ovarian cancer model, but the mice treated with 1.5 mg/kg daily, oral Topotecan show decreased food intake, and a lesser antitumor effect[2].
References	[1]. Zhang FL, et al. PLoS One. 2013 Nov 26;8(11):e81815.Topoisomerase I inhibitors, Shikonin and Topotecan, inhibit growth and induce apoptosis of glioma cells andglioma stem cells. [2]. Kumar S, et al. Metronomic oral topotecan with pazopanib is an active antiangiogenic regimen in mouse models of aggressive pediatric solid tumor. Clin Cancer Res. 2011 Sep 1;17(17):5656-67.

Molecular Formula	C₂₃H₂₆ClN₃O₆
Molecular Weight	475.92

123948-87-8	1044663-62-8
119413-54-6	186694-02-0
24968-67-0	154776-45-1
75708-29-1	1808255-64-2
206658-92-6	591229-40-2
1630900-07-0	1158522-08-7
940364-43-2	134104-43-1
131615-57-1	1510076-59-1
6906-52-1	930439-75-1
2062349-07-7	1627893-48-4