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2493052-22-3

2493052-22-3 structure

2493052-22-3 structure

Name: Tubulin polymerization-IN-22
Chemical Name: Tubulin polymerization-IN-22
CAS Number: 2493052-22-3
Molecular Formula: C₁₉H₁₆O₄
Molecular Weight: 308.33
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2022-08-17 12:26:10
Modify Date: 2025-08-27 19:19:23
Tubulin polymerization-IN-22 is a tubulin polymerization inhibitor with an IC50 of 8.1 μM. Tubulin polymerization-IN-22 arrests cell cycle at G2/M phase and induces apoptosis[1].

Name	Tubulin polymerization-IN-22

Description	Tubulin polymerization-IN-22 is a tubulin polymerization inhibitor with an IC50 of 8.1 μM. Tubulin polymerization-IN-22 arrests cell cycle at G2/M phase and induces apoptosis[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin
In Vitro	Tubulin polymerization-IN-22 (Compound 4u) shows antiproliferative activity against human breast cancer cell line (MCF-7) with an IC50 of 1.47 μM[1]. Tubulin polymerization-IN-22 (Compound 4u) is a tubulin polymerization inhibitor by targeting the Colchicine binding site[1].
References	[1]. Guangcheng Wang, et al. Design, synthesis, and anticancer evaluation of benzophenone derivatives bearing naphthalene moiety as novel tubulin polymerization inhibitors. Bioorg Chem. 2020 Nov;104:104265.

Molecular Formula	C₁₉H₁₆O₄
Molecular Weight	308.33

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