2413565-19-0
2413565-19-0 structure
- Name: COX-2-IN-26
- Chemical Name: COX-2-IN-26
- CAS Number: 2413565-19-0
- Molecular Formula: C23H21N7OS3
- Molecular Weight: 507.65
- Catalog: Signaling Pathways Immunology/Inflammation COX
- Create Date: 2022-09-04 19:14:19
- Modify Date: 2024-04-09 09:42:16
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COX-2-IN-26 is a potent, selective and orally active COX-2 inhibitor with IC50 values of 10.61, 0.067, 1.96 µM for COX-1, COX-2, 15-LOX, respectively. COX-2-IN-26 shows anti-inflammatory activity. COX-2-IN-26 shows gastrointestinal safety profile[1].
| Name | COX-2-IN-26 |
|---|
| Description | COX-2-IN-26 is a potent, selective and orally active COX-2 inhibitor with IC50 values of 10.61, 0.067, 1.96 µM for COX-1, COX-2, 15-LOX, respectively. COX-2-IN-26 shows anti-inflammatory activity. COX-2-IN-26 shows gastrointestinal safety profile[1]. |
|---|---|
| Related Catalog | |
| Target |
COX-2:0.067 μM (IC50) COX-1:10.61 μM (IC50) 15-LOX:1.96 μM (IC50) |
| In Vitro | COX-2-IN-26 (compound 16) shows significant COX-2 selectivity with an SI value of 158.36[1]. |
| In Vivo | COX-2-IN-26 (28 µM/kg) shows a potent anti-inflammatory activity in rats with edema inhibition relative to indomethacin of 102% and 119% in 4h and 3h, respectively[1]. .COX-2-IN-26 (10, 30, 50 mg/kg; p.o.) shows GI safety profile with normal appearance for mucosa with intact surface epithelium and preserves glands but there is some congestion of the blood vessels in albino rats[1]. |
| References |
| Molecular Formula | C23H21N7OS3 |
|---|---|
| Molecular Weight | 507.65 |