COX-2-IN-26

Modify Date: 2024-04-09 09:42:16

COX-2-IN-26 structure	Common Name	COX-2-IN-26
	CAS Number	2413565-19-0	Molecular Weight	507.65
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₃H₂₁N₇OS₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of COX-2-IN-26

COX-2-IN-26 is a potent, selective and orally active COX-2 inhibitor with IC50 values of 10.61, 0.067, 1.96 µM for COX-1, COX-2, 15-LOX, respectively. COX-2-IN-26 shows anti-inflammatory activity. COX-2-IN-26 shows gastrointestinal safety profile[1].

Name	COX-2-IN-26

Description	COX-2-IN-26 is a potent, selective and orally active COX-2 inhibitor with IC50 values of 10.61, 0.067, 1.96 µM for COX-1, COX-2, 15-LOX, respectively. COX-2-IN-26 shows anti-inflammatory activity. COX-2-IN-26 shows gastrointestinal safety profile[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX
Target	COX-2:0.067 μM (IC50) COX-1:10.61 μM (IC50) 15-LOX:1.96 μM (IC50)
In Vitro	COX-2-IN-26 (compound 16) shows significant COX-2 selectivity with an SI value of 158.36[1].
In Vivo	COX-2-IN-26 (28 µM/kg) shows a potent anti-inflammatory activity in rats with edema inhibition relative to indomethacin of 102% and 119% in 4h and 3h, respectively[1]. .COX-2-IN-26 (10, 30, 50 mg/kg; p.o.) shows GI safety profile with normal appearance for mucosa with intact surface epithelium and preserves glands but there is some congestion of the blood vessels in albino rats[1].
References	[1]. Maghraby MT, et al. Novel class of benzimidazole-thiazole hybrids: The privileged scaffolds of potent anti-inflammatory activity with dual inhibition of cyclooxygenase and 15-lipoxygenase enzymes. Bioorg Med Chem. 2020 Apr 1;28(7):115403.

Molecular Formula	C₂₃H₂₁N₇OS₃
Molecular Weight	507.65

COX-2-IN-26

Use of COX-2-IN-26

Names

COX-2-IN-26 Biological Activity

Chemical & Physical Properties