2413565-17-8

2413565-17-8 structure

2413565-17-8 structure

Name: COX-2-IN-27
Chemical Name: COX-2-IN-27
CAS Number: 2413565-17-8
Molecular Formula: C₂₉H₂₄ClN₇S₃
Molecular Weight: 602.20
Catalog: Signaling Pathways Immunology/Inflammation COX
Create Date: 2022-09-04 16:42:17
Modify Date: 2024-01-10 11:02:58
COX-2-IN-27 is a potent and selective COX-2 inhibitor with IC50 values of 13.22, 0.045, 1.67 µM for COX-1, COX-2, 15-LOX, respectively. COX-2-IN-27 shows anti-inflammatory activity[1].

Name	COX-2-IN-27

Description	COX-2-IN-27 is a potent and selective COX-2 inhibitor with IC50 values of 13.22, 0.045, 1.67 µM for COX-1, COX-2, 15-LOX, respectively. COX-2-IN-27 shows anti-inflammatory activity[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX
Target	COX-1:13.22 μM (IC50) COX-2:0.045 μM (IC50) 15-LOX:1.67 μM (IC50)
In Vitro	COX-2-IN-27 (compound 15b) shows significant COX-2 selectivity with an SI value of 293.78[1].
In Vivo	COX-2-IN-27 (28 µM/kg) shows a potent anti-inflammatory activity in rats with edema inhibition relative to indomethacin of 93.20% and 109.08% in 4h and 3h, respectively[1].
References	[1]. Maghraby MT, et al. Novel class of benzimidazole-thiazole hybrids: The privileged scaffolds of potent anti-inflammatory activity with dual inhibition of cyclooxygenase and 15-lipoxygenase enzymes. Bioorg Med Chem. 2020 Apr 1;28(7):115403.

Molecular Formula	C₂₉H₂₄ClN₇S₃
Molecular Weight	602.20