COX-2-IN-27

Modify Date: 2024-01-10 11:02:58

COX-2-IN-27 Structure
COX-2-IN-27 structure
Common Name COX-2-IN-27
CAS Number 2413565-17-8 Molecular Weight 602.20
Density N/A Boiling Point N/A
Molecular Formula C29H24ClN7S3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of COX-2-IN-27


COX-2-IN-27 is a potent and selective COX-2 inhibitor with IC50 values of 13.22, 0.045, 1.67 µM for COX-1, COX-2, 15-LOX, respectively. COX-2-IN-27 shows anti-inflammatory activity[1].

 Names

Name COX-2-IN-27

 COX-2-IN-27 Biological Activity

Description COX-2-IN-27 is a potent and selective COX-2 inhibitor with IC50 values of 13.22, 0.045, 1.67 µM for COX-1, COX-2, 15-LOX, respectively. COX-2-IN-27 shows anti-inflammatory activity[1].
Related Catalog
Target

COX-1:13.22 μM (IC50)

COX-2:0.045 μM (IC50)

15-LOX:1.67 μM (IC50)

In Vitro COX-2-IN-27 (compound 15b) shows significant COX-2 selectivity with an SI value of 293.78[1].
In Vivo COX-2-IN-27 (28 µM/kg) shows a potent anti-inflammatory activity in rats with edema inhibition relative to indomethacin of 93.20% and 109.08% in 4h and 3h, respectively[1].
References

[1]. Maghraby MT, et al. Novel class of benzimidazole-thiazole hybrids: The privileged scaffolds of potent anti-inflammatory activity with dual inhibition of cyclooxygenase and 15-lipoxygenase enzymes. Bioorg Med Chem. 2020 Apr 1;28(7):115403.

 Chemical & Physical Properties

Molecular Formula C29H24ClN7S3
Molecular Weight 602.20