COX-2-IN-27 structure
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Common Name | COX-2-IN-27 | ||
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CAS Number | 2413565-17-8 | Molecular Weight | 602.20 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C29H24ClN7S3 | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of COX-2-IN-27COX-2-IN-27 is a potent and selective COX-2 inhibitor with IC50 values of 13.22, 0.045, 1.67 µM for COX-1, COX-2, 15-LOX, respectively. COX-2-IN-27 shows anti-inflammatory activity[1]. |
Name | COX-2-IN-27 |
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Description | COX-2-IN-27 is a potent and selective COX-2 inhibitor with IC50 values of 13.22, 0.045, 1.67 µM for COX-1, COX-2, 15-LOX, respectively. COX-2-IN-27 shows anti-inflammatory activity[1]. |
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Related Catalog | |
Target |
COX-1:13.22 μM (IC50) COX-2:0.045 μM (IC50) 15-LOX:1.67 μM (IC50) |
In Vitro | COX-2-IN-27 (compound 15b) shows significant COX-2 selectivity with an SI value of 293.78[1]. |
In Vivo | COX-2-IN-27 (28 µM/kg) shows a potent anti-inflammatory activity in rats with edema inhibition relative to indomethacin of 93.20% and 109.08% in 4h and 3h, respectively[1]. |
References |
Molecular Formula | C29H24ClN7S3 |
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Molecular Weight | 602.20 |