1888305-85-8
1888305-85-8 structure
- Name: ERK5-IN-3
- Chemical Name: ERK5-IN-3
- CAS Number: 1888305-85-8
- Molecular Formula: C24H23Cl2FN4O2
- Molecular Weight: 489.37
- Catalog: Signaling Pathways MAPK/ERK Pathway ERK
- Create Date: 2022-09-21 12:20:51
- Modify Date: 2024-07-17 12:16:05
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ERK5-IN-3 (compound 33j) is a potent and selective ERK5 (extracellular signal-related kinase 5) inhibitor, with an IC50 of 6 nM. ERK5-IN-3 shows antiproliferation activity against Hela cells, with an IC50 of 31 nM[1].
| Name | ERK5-IN-3 |
|---|
| Description | ERK5-IN-3 (compound 33j) is a potent and selective ERK5 (extracellular signal-related kinase 5) inhibitor, with an IC50 of 6 nM. ERK5-IN-3 shows antiproliferation activity against Hela cells, with an IC50 of 31 nM[1]. |
|---|---|
| Related Catalog | |
| Target |
ERK5:6 ± 1 nM (IC50) |
| In Vivo | ERK5-IN-3 (compound 33j) (10 mg/kg, i.v. and p.o, once) has low clearance (CL=20 mL/min/kg) and low oral bioavailability (F%=9%), with terminal elimination half-lives of 263 min[1]. |
| References |
| Molecular Formula | C24H23Cl2FN4O2 |
|---|---|
| Molecular Weight | 489.37 |