1888305-85-8

1888305-85-8 structure

1888305-85-8 structure

Name: ERK5-IN-3
Chemical Name: ERK5-IN-3
CAS Number: 1888305-85-8
Molecular Formula: C₂₄H₂₃Cl₂FN₄O₂
Molecular Weight: 489.37
Catalog: Signaling Pathways MAPK/ERK Pathway ERK
Create Date: 2022-09-21 12:20:51
Modify Date: 2023-02-06 07:09:49
ERK5-IN-3 (compound 33j) is a potent and selective ERK5 (extracellular signal-related kinase 5) inhibitor, with an IC50 of 6 nM. ERK5-IN-3 shows antiproliferation activity against Hela cells, with an IC50 of 31 nM[1].

Name	ERK5-IN-3

Description	ERK5-IN-3 (compound 33j) is a potent and selective ERK5 (extracellular signal-related kinase 5) inhibitor, with an IC50 of 6 nM. ERK5-IN-3 shows antiproliferation activity against Hela cells, with an IC50 of 31 nM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> MAPK/ERK Pathway >> ERK Signaling Pathways >> Stem Cell/Wnt >> ERK
Target	ERK5:6 ± 1 nM (IC50)
In Vivo	ERK5-IN-3 (compound 33j) (10 mg/kg, i.v. and p.o, once) has low clearance (CL=20 mL/min/kg) and low oral bioavailability (F%=9%), with terminal elimination half-lives of 263 min[1].
References	[1]. Miller DC, et al. Parallel Optimization of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor. J Med Chem. 2022 May 12;65(9):6513-6540.

Molecular Formula	C₂₄H₂₃Cl₂FN₄O₂
Molecular Weight	489.37