ERK5-IN-3

Modify Date: 2024-07-17 12:16:05

ERK5-IN-3 structure	Common Name	ERK5-IN-3
	CAS Number	1888305-85-8	Molecular Weight	489.37
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₄H₂₃Cl₂FN₄O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of ERK5-IN-3

ERK5-IN-3 (compound 33j) is a potent and selective ERK5 (extracellular signal-related kinase 5) inhibitor, with an IC50 of 6 nM. ERK5-IN-3 shows antiproliferation activity against Hela cells, with an IC50 of 31 nM[1].

Name	ERK5-IN-3

Description	ERK5-IN-3 (compound 33j) is a potent and selective ERK5 (extracellular signal-related kinase 5) inhibitor, with an IC50 of 6 nM. ERK5-IN-3 shows antiproliferation activity against Hela cells, with an IC50 of 31 nM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> MAPK/ERK Pathway >> ERK Signaling Pathways >> Stem Cell/Wnt >> ERK
Target	ERK5:6 ± 1 nM (IC50)
In Vivo	ERK5-IN-3 (compound 33j) (10 mg/kg, i.v. and p.o, once) has low clearance (CL=20 mL/min/kg) and low oral bioavailability (F%=9%), with terminal elimination half-lives of 263 min[1].
References	[1]. Miller DC, et al. Parallel Optimization of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor. J Med Chem. 2022 May 12;65(9):6513-6540.

Molecular Formula	C₂₄H₂₃Cl₂FN₄O₂
Molecular Weight	489.37