2230475-63-3

2230475-63-3 structure

Name: KDM4-IN-4
Chemical Name: KDM4-IN-4
CAS Number: 2230475-63-3
Molecular Formula: C₁₆H₂₃NO
Molecular Weight: 245.36
Catalog: Signaling Pathways Epigenetics Histone Demethylase
Create Date: 2022-08-31 19:14:45
Modify Date: 2024-09-20 16:32:01
KDM4-IN-4 (compound 47) is a potent histone lysine demethylase 4 (KDM4) inhibitor with a modest affinity binding to ~80 μM for KDM4A-Tudor domain. KDM4-IN-4 can inhibit H3K4Me3 binding to the Tudor domain in cells with an EC50 value of 105 μM. KDM4-IN-4 can be used for researching anticancer[1].

Name	KDM4-IN-4

Description	KDM4-IN-4 (compound 47) is a potent histone lysine demethylase 4 (KDM4) inhibitor with a modest affinity binding to ~80 μM for KDM4A-Tudor domain. KDM4-IN-4 can inhibit H3K4Me3 binding to the Tudor domain in cells with an EC50 value of 105 μM. KDM4-IN-4 can be used for researching anticancer[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Histone Demethylase
Target	KDM4A-Tudor domain:80 μM (Ki)
References	[1]. Wu Q, Young B, Wang Y, Davidoff AM, Rankovic Z, Yang J. Recent Advances with KDM4 Inhibitors and Potential Applications. J Med Chem. 2022 Jul 15.

Molecular Formula	C₁₆H₂₃NO
Molecular Weight	245.36