2417283-44-2
2417283-44-2 structure
- Name: MI-1851
- Chemical Name: MI-1851
- CAS Number: 2417283-44-2
- Molecular Formula: C34H53N15O6
- Molecular Weight: 767.88
- Catalog: Signaling Pathways Anti-infection SARS-CoV
- Create Date: 2022-09-01 11:39:09
- Modify Date: 2025-08-22 14:59:00
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MI-1851 is a potent furin inhibitor. MI-1851 prevents the proteolytic processing of the S protein of SARS-CoV-2 by endogenous flavoprotease in HEK293 cells. MI-185 has antiviral activity[1][2].
| Name | MI-1851 |
|---|
| Description | MI-1851 is a potent furin inhibitor. MI-1851 prevents the proteolytic processing of the S protein of SARS-CoV-2 by endogenous flavoprotease in HEK293 cells. MI-185 has antiviral activity[1][2]. |
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| Related Catalog | |
| In Vitro | MI-1851 (0-100 μM, 2h, 24 h) does not affect PHH cells viability, and extracellular hydrogen peroxide production even at 100 μM but reduces CYP3A4 isoenzyme activity in PHH cells in a dose-dependent manner[1]. MI-1851 (10-50 μM, 72 h) strongly inhibits the spread of SARS-CoV-2 and its proliferation in Calu-3 cells even at a low dose of 10 μM, which reduces the virus titer by 30 to 190-fold[2]. MI-1851 (compound 8) (0.5-16 μM, 48 h) inhibits DENV-2 and WNV replication with the EC50 values of 1.50 μM and 1.46 μM, respectively in huh-7 cells[3]. |
| In Vivo | Animal Model: Rats[3] Dosage: 2.5 mg/kg Administration: Intravenous injection; once Result: The pharmacokinetic parameters of MI-1851 (compound 8) Parameter MI-1851 (compound 8) t1/2 1.6 h total body clearance 273 mL/(h•kg) Cmax 3156 ng/mL |
| References |
| Molecular Formula | C34H53N15O6 |
|---|---|
| Molecular Weight | 767.88 |