893633-37-9

893633-37-9 structure

Name: PROTAC BRD9-binding moiety 5
Chemical Name: PROTAC BRD9-binding moiety 5
CAS Number: 893633-37-9
Molecular Formula: C₁₉H₁₈N₆O
Molecular Weight: 346.39
Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
Create Date: 2022-09-12 12:15:57
Modify Date: 2024-07-17 10:55:43
PROTAC BRD9-binding moiety 5 is a selective BRD9 binder with an IC50 value of 4.20 μM, can be used for the synthesis of PROTACs. PROTAC BRD9-binding moiety 5 has antiproliferative activity against cancer cells[1].

Name	PROTAC BRD9-binding moiety 5

Description	PROTAC BRD9-binding moiety 5 is a selective BRD9 binder with an IC50 value of 4.20 μM, can be used for the synthesis of PROTACs. PROTAC BRD9-binding moiety 5 has antiproliferative activity against cancer cells[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain
Target	BRD9:4.2 μM (IC50)
In Vitro	PROTAC BRD9-binding moiety 5 (compound 7) (0-250 μM; 48h) has antiproliferative activity against Jurkat, MDA-MB-231, A375 and HCT-116[1]. Cell Proliferation Assay[1] Cell Line: Jurkat, MDA-MB-231, A375 and HCT-116 Concentration: 0-250 μM Incubation Time: 48h Result: Exhibited antiproliferative activity against Jurkat, MDA-MB-231, A375 and HCT-116 with IC50s of 77 ± 7 μM, 125 ± 8 μM, 133 ± 5 μM and 145 ± 3 μM.
References	[1]. Pierri M, et al. Introducing structure-based three-dimensional pharmacophore models for accelerating the discovery of selective BRD9 binders. Bioorg Chem. 2022 Jan;118:105480.

Molecular Formula	C₁₉H₁₈N₆O
Molecular Weight	346.39