1093082-54-2

1093082-54-2 structure

Name: Renin inhibitor-1
Chemical Name: Renin inhibitor-1
CAS Number: 1093082-54-2
Molecular Formula: C₂₂H₃₀N₄O₄
Molecular Weight: 414.50
Catalog: Signaling Pathways Metabolic Enzyme/Protease Renin
Create Date: 2022-09-10 18:50:29
Modify Date: 2024-01-02 17:21:26
Renin inhibitor-1 (compound 26) is a potent and orally active renin inhibitor with IC50s of 0.9, 1.8 nM for rh-renin and hPRA, respectively. Renin inhibitor-1 shows antihypertensive efficacy. Renin inhibitor-1 has the potential for the research of hypertension and cardiovascular/renal diseases[1].

Name	Renin inhibitor-1

Description	Renin inhibitor-1 (compound 26) is a potent and orally active renin inhibitor with IC50s of 0.9, 1.8 nM for rh-renin and hPRA, respectively. Renin inhibitor-1 shows antihypertensive efficacy. Renin inhibitor-1 has the potential for the research of hypertension and cardiovascular/renal diseases[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Renin
Target	IC50: 0.9 nM (rh-renin); 1.8 nM (hPRA)[1]
In Vivo	Renin inhibitor-1 (compound 26) (10 mg/kg; p.o.) demonstrates a significantly potent hypotensive effect in tsukuba hypertensive mice[1].
References	[1]. Daisuke Iijima, et al. Discovery of Novel 2-Carbamoyl Morpholine Derivatives as Highly Potent and Orally Active Direct Renin Inhibitors. ACS Med. Chem. Lett. 2022, 13, 8, 1351–1357.

Molecular Formula	C₂₂H₃₀N₄O₄
Molecular Weight	414.50