1010888-06-8
1010888-06-8 structure
- Name: ZINC12409120
- Chemical Name: ZINC12409120
- CAS Number: 1010888-06-8
- Molecular Formula: C20H16N4O2
- Molecular Weight: 344.37
- Catalog: Signaling Pathways MAPK/ERK Pathway ERK
- Create Date: 2022-09-10 21:51:57
- Modify Date: 2024-09-19 12:10:11
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ZINC12409120 is a high selective ERK inhibitor. ZINC12409120 acts on disrupting FGF23:α-Klotho interaction to inhibit ERK activity with an IC50 of 5.0 μM[1].
| Name | ZINC12409120 |
|---|
| Description | ZINC12409120 is a high selective ERK inhibitor. ZINC12409120 acts on disrupting FGF23:α-Klotho interaction to inhibit ERK activity with an IC50 of 5.0 μM[1]. |
|---|---|
| Related Catalog | |
| Target |
ERK:5 μM (IC50) |
| In Vitro | FGF23 induces hypophosphatemia, mediated by ternary complex formed by FGF23, the FGF receptor (FGFR), and α-Klotho[1]. ZINC12409120 (1 nM-0.1 mM; 5 h) inhibits ERK reporter activities mediated by FGF23 (1 μM), with an IC50 of 5 μM[1]. ZINC12409120 (10 μM; 5 h) specificaly inhibits ERK activity mediated by FGF23:α-Klotho instead of EGF-mediated ERK activation, and exhibits no inhibitory effect on EGFR tyrosine kinase or EGF/EGFR interaction[1]. ZINC12409120 has an half-life of 8.4 h, predicted by pkCSM64 (http://biosig.unimelb.edu.au/pkcsm/)[1]. Cell Proliferation Assay[1] Cell Line: Human embryonic kidney (HEK) 293T cells Concentration: 1 nM-0.1 mM Incubation Time: 5 hours Result: Inhibited FGF23-mediated ERK reporter activity in a dose-dependent manner, with an IC50 of 5 μM. And reduced FGF23-mediated ERK activities by 70%, as well. |
| References |
| Molecular Formula | C20H16N4O2 |
|---|---|
| Molecular Weight | 344.37 |