1795037-48-7

1795037-48-7 structure

Name: Rufinamide
Chemical Name: 1-[dideuterio-(2,6-difluorophenyl)methyl]triazole-4-carboxamide
CAS Number: 1795037-48-7
Molecular Formula: C₁₀H₆D₂F₂N₄O
Molecular Weight: 240.205849956
Catalog: Research Areas Neurological Disease
Create Date: 2022-10-09 19:47:48
Modify Date: 2024-01-13 12:15:13
Rufinamide-15N,d2 is the deuterium and 15N labeled Rufinamide[1]. Rufinamide is a new antiepileptic agent that differs structurally from other antiepileptic drugs and is approved as adjunctive therapy for Lennox-Gastaut syndrome (LGS)[2][3].

Name	1-[dideuterio-(2,6-difluorophenyl)methyl]triazole-4-carboxamide

Description	Rufinamide-15N,d2 is the deuterium and 15N labeled Rufinamide[1]. Rufinamide is a new antiepileptic agent that differs structurally from other antiepileptic drugs and is approved as adjunctive therapy for Lennox-Gastaut syndrome (LGS)[2][3].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Suter MR, Kirschmann G, Laedermann CJ, Rufinamide attenuates mechanical allodynia in a model of neuropathic pain in the mouse and stabilizes voltage-gated sodium channel inactivated state. Anesthesiology. 2013 Jan;118(1):160-72. [3]. White HS, Franklin MR, Kupferberg HJ, The anticonvulsant profile of rufinamide (CGP 33101) in rodent seizure models. Epilepsia. 2008 Jul;49(7):1213-20.

Molecular Formula	C₁₀H₆D₂F₂N₄O
Molecular Weight	240.205849956

1795037-48-7	106308-44-5
106308-41-2	217448-86-7