99330-28-6

99330-28-6 structure

Name: Antibacterial agent 116
Chemical Name: Antibacterial agent 116
CAS Number: 99330-28-6
Molecular Formula: C₂₆H₁₅Cl₂I₂NO₄
Molecular Weight: 730.12
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2022-10-07 09:57:20
Modify Date: 2024-01-06 12:06:43
Antibacterial agent 116 is a benzophenone-containing salicylanilide compound. Antibacterial agent 116 has potent antibacterial activity by inhibiting the peptidoglycan formation. Antibacterial agent 116 is used as a photoaffinity probe to label Acinetobacter baumannii penicillin-binding protein (PBP1b), block the propagation pathway to disrupt the growth of peptidoglycan chain[1].

Name	Antibacterial agent 116

Description	Antibacterial agent 116 is a benzophenone-containing salicylanilide compound. Antibacterial agent 116 has potent antibacterial activity by inhibiting the peptidoglycan formation. Antibacterial agent 116 is used as a photoaffinity probe to label Acinetobacter baumannii penicillin-binding protein (PBP1b), block the propagation pathway to disrupt the growth of peptidoglycan chain[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Antibacterial agent 116 (compound 1) can photo-label A. baumannii PBP1b, targets to R367 and E372 binding site[1].
References	[1]. Chuang HC, et al. Photoaffinity labeling of benzophenone-containing salicylanilide compounds to give an insight into the mechanism in disrupting peptidoglycan formation. Bioorg Med Chem. 2022 Aug 1;67:116819.

Molecular Formula	C₂₆H₁₅Cl₂I₂NO₄
Molecular Weight	730.12