883027-32-5

883027-32-5 structure

Name: DSS30
Chemical Name: DSS30
CAS Number: 883027-32-5
Molecular Formula: C₁₆H₁₄ClNO₃S₂
Molecular Weight: 367.87
Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
Create Date: 2022-10-12 13:32:27
Modify Date: 2024-02-24 18:13:49
DSS30 is a P25/CDK5 inhibitor that reduces β-amyloid (Aβ) secretion by inhibiting amyloid precursor protein lyase 1 (BACEl) phosphorylation. DSS30 can be used in the study of neurodegenerative diseases such as Alzheimer's disease[1].

Name	DSS30

Description	DSS30 is a P25/CDK5 inhibitor that reduces β-amyloid (Aβ) secretion by inhibiting amyloid precursor protein lyase 1 (BACEl) phosphorylation. DSS30 can be used in the study of neurodegenerative diseases such as Alzheimer's disease[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Cell Cycle/DNA Damage >> CDK
In Vitro	DSS30 (50 μM, 2 hours) inhibits the activity of the P25/CDK5 complex by up to 50% and the phosphorylation of BACE1 or Tau[1]. Western Blot Analysis[1] Cell Line: Expressed P25 PC12tet-off cell lines Concentration: 50 μM Incubation Time: 8 hours Result: Inhibited BACE1 phosphorylation by 12%.
References	[1]. Sul-Hee Chung, et al. Pharmaceutical composition comprising a p25/cdk5 inhibitor for preventing or treating a neurodegenerative disease. WO2006075808

Molecular Formula	C₁₆H₁₄ClNO₃S₂
Molecular Weight	367.87