883956-47-6
883956-47-6 structure
- Name: SRI-37240
- Chemical Name: SRI-37240
- CAS Number: 883956-47-6
- Molecular Formula: C24H23N3O2
- Molecular Weight: 385.46
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel CFTR
- Create Date: 2022-10-06 21:56:05
- Modify Date: 2024-01-24 16:54:12
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SRI-37240 is a potent premature termination codons (PTCs) inhibitor. SRI-37240 suppresses CFTR nonsense mutations. SRI-37240 alters cellular translation termination at PTCs in HEK293T cells. SRI-37240 can also restore CFTR function in primary bronchial epithelial cells when combination with G418[1].
| Name | SRI-37240 |
|---|
| Description | SRI-37240 is a potent premature termination codons (PTCs) inhibitor. SRI-37240 suppresses CFTR nonsense mutations. SRI-37240 alters cellular translation termination at PTCs in HEK293T cells. SRI-37240 can also restore CFTR function in primary bronchial epithelial cells when combination with G418[1]. |
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| Related Catalog | |
| Target |
Premature termination codons, CFTR[1] |
| In Vitro | SRI-37240 (1, 3, 10 and 30 µM; 48 h) induces concentration-dependent increases in CFTR-dependent (Forskolin-stimulated and sensitive to the inhibitor CFTRInh-172) chloride conductance[1]. SRI-37240 (10 µM; 72 h) significantly increases the amount of full-length, fully glycosylated form of CFTR protein, and the unprocessed, immature form of full-length CFTR protein in 16HBEge cells when co-treated with G418 (100 µM)[1]. SRI-37240 (10 µM; 24 h) alters cellular translation termination at PTCs in HEK293T cells, also increases global densities of ribosomes at normal stop codons without affecting densities of ribosomes in 3-UTRs[1]. SRI-37240 (10 µM; 72 h) restores CFTR function in primary bronchial epithelial cells when combination with G418[1]. Western Blot Analysis[1] Cell Line: CFTR-G542X 16HBEge Concentration: 10 µM Incubation Time: 24 h Result: Significantly increased the amount of Band C CFTR protein, which represents the full-length, fully glycosylated form of CFTR and Band B, which represents the unprocessed, immature form of full-length CFTR protein when combined with G418 (100 µM). |
| References |
| Molecular Formula | C24H23N3O2 |
|---|---|
| Molecular Weight | 385.46 |