1885900-35-5

1885900-35-5 structure

Name: Phenol, 2-[6-fluoro-3-[[(4-methoxyphenyl)methyl]amino]imidazo[1,2-a]pyridin-2-yl]-
Chemical Name: Antiproliferative agent-14
CAS Number: 1885900-35-5
Molecular Formula: C₂₁H₁₈FN₃O₂
Molecular Weight: 363.38
Catalog: Signaling Pathways Cell Cycle/DNA Damage Microtubule/Tubulin
Create Date: 2022-11-21 10:55:31
Modify Date: 2024-04-02 19:38:06
Antiproliferative agent-14 (compound 3b) a potent tubulin polymerization inhibitor, with an IC50 of 3.41 μM. Antiproliferative agent-14 has excellent antiproliferative activity. Antiproliferative agent-14 possess the ability to arrest cells at G2/M phases of the cell cycle[1].

Name	Antiproliferative agent-14

Description	Antiproliferative agent-14 (compound 3b) a potent tubulin polymerization inhibitor, with an IC50 of 3.41 μM. Antiproliferative agent-14 has excellent antiproliferative activity. Antiproliferative agent-14 possess the ability to arrest cells at G2/M phases of the cell cycle[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin
In Vitro	Antiproliferative agent-14 (compound 3b) shows antiproliferative activity against HeLa cell (IC50=13 nM)[1]. Antiproliferative agent-14 shows inhibition of colchicine binding activity, with 72.2% inhibitory percentage[1].
References	[1]. An W, et al. Discovery of novel 2-phenyl-imidazo[1,2-a]pyridine analogues targeting tubulin polymerization as antiproliferative agents. Eur J Med Chem. 2016 Apr 13;112:367-372.

Molecular Formula	C₂₁H₁₈FN₃O₂
Molecular Weight	363.38