Phenol, 2-[6-fluoro-3-[[(4-methoxyphenyl)methyl]amino]imidazo[1,2-a]pyridin-2-yl]-

Modify Date: 2024-04-02 19:38:06

Phenol, 2-[6-fluoro-3-[[(4-methoxyphenyl)methyl]amino]imidazo[1,2-a]pyridin-2-yl]- Structure
Phenol, 2-[6-fluoro-3-[[(4-methoxyphenyl)methyl]amino]imidazo[1,2-a]pyridin-2-yl]- structure
Common Name Phenol, 2-[6-fluoro-3-[[(4-methoxyphenyl)methyl]amino]imidazo[1,2-a]pyridin-2-yl]-
CAS Number 1885900-35-5 Molecular Weight 363.38
Density N/A Boiling Point N/A
Molecular Formula C21H18FN3O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Phenol, 2-[6-fluoro-3-[[(4-methoxyphenyl)methyl]amino]imidazo[1,2-a]pyridin-2-yl]-


Antiproliferative agent-14 (compound 3b) a potent tubulin polymerization inhibitor, with an IC50 of 3.41 μM. Antiproliferative agent-14 has excellent antiproliferative activity. Antiproliferative agent-14 possess the ability to arrest cells at G2/M phases of the cell cycle[1].

 Names

Name Antiproliferative agent-14

  Biological Activity

Description Antiproliferative agent-14 (compound 3b) a potent tubulin polymerization inhibitor, with an IC50 of 3.41 μM. Antiproliferative agent-14 has excellent antiproliferative activity. Antiproliferative agent-14 possess the ability to arrest cells at G2/M phases of the cell cycle[1].
Related Catalog
In Vitro Antiproliferative agent-14 (compound 3b) shows antiproliferative activity against HeLa cell (IC50=13 nM)[1]. Antiproliferative agent-14 shows inhibition of colchicine binding activity, with 72.2% inhibitory percentage[1].
References

[1]. An W, et al. Discovery of novel 2-phenyl-imidazo[1,2-a]pyridine analogues targeting tubulin polymerization as antiproliferative agents. Eur J Med Chem. 2016 Apr 13;112:367-372.

 Chemical & Physical Properties

Molecular Formula C21H18FN3O2
Molecular Weight 363.38
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