2839318-19-1
2839318-19-1 structure
- Name: dBRD4-BD1
- Chemical Name: dBRD4-BD1
- CAS Number: 2839318-19-1
- Molecular Formula: C50H53F3N8O9
- Molecular Weight: 967.00
- Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
- Create Date: 2022-11-12 00:16:39
- Modify Date: 2024-04-09 12:38:19
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dBRD4-BD1 is a selective and durable BRD4 degrader with an DC50 value of 280 nM (Dmax=77%). dBRD4-BD1 upregulates BRD2/3 protein level and shows low cytotoxicity than iBRD4-BD1[1].
| Name | dBRD4-BD1 |
|---|
| Description | dBRD4-BD1 is a selective and durable BRD4 degrader with an DC50 value of 280 nM (Dmax=77%). dBRD4-BD1 upregulates BRD2/3 protein level and shows low cytotoxicity than iBRD4-BD1[1]. |
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| Related Catalog | |
| In Vitro | dBRD4-BD1 (64 pM-25 nM; 24 h) degrades BDR4 in a dose-dependent manner[1]. dBRD4-BD1 (5 μM; 0-72 h) increases the protein level of BRD2 and BRD3[1]. Western Blot Analysis[1] Cell Line: MM.1S cells Concentration: 25, 5, 1, 0.2, 0.04, 0.008, 0.0016 nM and 320 pM, 64 pM Incubation Time: 24 hours Result: Degraded BDR4 in a dose-dependent manner. Western Blot Analysis[1] Cell Line: MM.1S cells Concentration: 5 μM Incubation Time: 0, 0.5, 1, 2, 4, 8, 12, 24, 30, 36, 48, 72 hours Result: Increased the protein amount of BRD2 and BRD3 without decreasing cMyc protein level in 4 hr period. |
| References |
| Molecular Formula | C50H53F3N8O9 |
|---|---|
| Molecular Weight | 967.00 |