dBRD4-BD1

Modify Date: 2024-04-09 12:38:19

dBRD4-BD1 Structure
dBRD4-BD1 structure
Common Name dBRD4-BD1
CAS Number 2839318-19-1 Molecular Weight 967.00
Density N/A Boiling Point N/A
Molecular Formula C50H53F3N8O9 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of dBRD4-BD1


dBRD4-BD1 is a selective and durable BRD4 degrader with an DC50 value of 280 nM (Dmax=77%). dBRD4-BD1 upregulates BRD2/3 protein level and shows low cytotoxicity than iBRD4-BD1[1].

 Names

Name dBRD4-BD1

 dBRD4-BD1 Biological Activity

Description dBRD4-BD1 is a selective and durable BRD4 degrader with an DC50 value of 280 nM (Dmax=77%). dBRD4-BD1 upregulates BRD2/3 protein level and shows low cytotoxicity than iBRD4-BD1[1].
Related Catalog
In Vitro dBRD4-BD1 (64 pM-25 nM; 24 h) degrades BDR4 in a dose-dependent manner[1]. dBRD4-BD1 (5 μM; 0-72 h) increases the protein level of BRD2 and BRD3[1]. Western Blot Analysis[1] Cell Line: MM.1S cells Concentration: 25, 5, 1, 0.2, 0.04, 0.008, 0.0016 nM and 320 pM, 64 pM Incubation Time: 24 hours Result: Degraded BDR4 in a dose-dependent manner. Western Blot Analysis[1] Cell Line: MM.1S cells Concentration: 5 μM Incubation Time: 0, 0.5, 1, 2, 4, 8, 12, 24, 30, 36, 48, 72 hours Result: Increased the protein amount of BRD2 and BRD3 without decreasing cMyc protein level in 4 hr period.
References

[1]. Divakaran A, et al. Development of an N-Terminal BRD4 Bromodomain-Targeted Degrader. ACS Med Chem Lett. 2022 Sep 29;13(10):1621-1627.

 Chemical & Physical Properties

Molecular Formula C50H53F3N8O9
Molecular Weight 967.00
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