![]() dBRD4-BD1 structure
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Common Name | dBRD4-BD1 | ||
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CAS Number | 2839318-19-1 | Molecular Weight | 967.00 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C50H53F3N8O9 | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of dBRD4-BD1dBRD4-BD1 is a selective and durable BRD4 degrader with an DC50 value of 280 nM (Dmax=77%). dBRD4-BD1 upregulates BRD2/3 protein level and shows low cytotoxicity than iBRD4-BD1[1]. |
Name | dBRD4-BD1 |
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Description | dBRD4-BD1 is a selective and durable BRD4 degrader with an DC50 value of 280 nM (Dmax=77%). dBRD4-BD1 upregulates BRD2/3 protein level and shows low cytotoxicity than iBRD4-BD1[1]. |
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Related Catalog | |
In Vitro | dBRD4-BD1 (64 pM-25 nM; 24 h) degrades BDR4 in a dose-dependent manner[1]. dBRD4-BD1 (5 μM; 0-72 h) increases the protein level of BRD2 and BRD3[1]. Western Blot Analysis[1] Cell Line: MM.1S cells Concentration: 25, 5, 1, 0.2, 0.04, 0.008, 0.0016 nM and 320 pM, 64 pM Incubation Time: 24 hours Result: Degraded BDR4 in a dose-dependent manner. Western Blot Analysis[1] Cell Line: MM.1S cells Concentration: 5 μM Incubation Time: 0, 0.5, 1, 2, 4, 8, 12, 24, 30, 36, 48, 72 hours Result: Increased the protein amount of BRD2 and BRD3 without decreasing cMyc protein level in 4 hr period. |
References |
Molecular Formula | C50H53F3N8O9 |
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Molecular Weight | 967.00 |