2743576-55-6

2743576-55-6 structure

2743576-55-6 structure

Name: ERK-IN-2 free base
Chemical Name: ERK-IN-2 free base
CAS Number: 2743576-55-6
Molecular Formula: C₁₆H₁₇N₅O₂
Molecular Weight: 311.34
Catalog: Signaling Pathways MAPK/ERK Pathway ERK
Create Date: 2022-11-21 11:33:21
Modify Date: 2024-02-03 09:19:24
ERK-IN-2 free base is a ERK2 inhibitor with an IC50 value of 1.8 nM. ERK-IN-2 free base might lead to off-target toxicity and/or off-target activity at dose >10 μM[1].

Name	ERK-IN-2 free base

Description	ERK-IN-2 free base is a ERK2 inhibitor with an IC50 value of 1.8 nM. ERK-IN-2 free base might lead to off-target toxicity and/or off-target activity at dose >10 μM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> MAPK/ERK Pathway >> ERK Signaling Pathways >> Stem Cell/Wnt >> ERK
Target	ERK2:1.8 nM (IC50)
In Vitro	ERK-IN-2 (ERKi) inhibits RSK phosphorylation with an IC50 of 280 nM[1]. ERK-IN-2 (ERKi, 1 μM) inhibits cell proliferation in cancer cell lines, with IC50 values of 214 nM; 305 nM; 91 nM and 201 nM for A375SM cell, SK-MEL 30 cell; Colo 205 cell and Lovo cell, respectively[1].
In Vivo	ERK-IN-2 (1 mpk, p.o.; or 0.5 mpk, i.v.; rat) shows a t1/2 of 0.4 h, and F% of 13%[1].
References	[1]. MRK-ERK Inhibitor and Negative Control.

Molecular Formula	C₁₆H₁₇N₅O₂
Molecular Weight	311.34