ERK-IN-2 free base

Modify Date: 2024-02-03 09:19:24

ERK-IN-2 free base structure	Common Name	ERK-IN-2 free base
	CAS Number	2743576-55-6	Molecular Weight	311.34
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₆H₁₇N₅O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of ERK-IN-2 free base

ERK-IN-2 free base is a ERK2 inhibitor with an IC50 value of 1.8 nM. ERK-IN-2 free base might lead to off-target toxicity and/or off-target activity at dose >10 μM[1].

Name	ERK-IN-2 free base

Description	ERK-IN-2 free base is a ERK2 inhibitor with an IC50 value of 1.8 nM. ERK-IN-2 free base might lead to off-target toxicity and/or off-target activity at dose >10 μM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> MAPK/ERK Pathway >> ERK Signaling Pathways >> Stem Cell/Wnt >> ERK
Target	ERK2:1.8 nM (IC50)
In Vitro	ERK-IN-2 (ERKi) inhibits RSK phosphorylation with an IC50 of 280 nM[1]. ERK-IN-2 (ERKi, 1 μM) inhibits cell proliferation in cancer cell lines, with IC50 values of 214 nM; 305 nM; 91 nM and 201 nM for A375SM cell, SK-MEL 30 cell; Colo 205 cell and Lovo cell, respectively[1].
In Vivo	ERK-IN-2 (1 mpk, p.o.; or 0.5 mpk, i.v.; rat) shows a t1/2 of 0.4 h, and F% of 13%[1].
References	[1]. MRK-ERK Inhibitor and Negative Control.

Molecular Formula	C₁₆H₁₇N₅O₂
Molecular Weight	311.34