2397679-88-6
2397679-88-6 structure
- Name: PI3KC2α-IN-3
- Chemical Name: PI3KC2α-IN-3
- CAS Number: 2397679-88-6
- Molecular Formula: C26H23N7O4S3
- Molecular Weight: 593.70
- Catalog: Signaling Pathways PI3K/Akt/mTOR PI3K
- Create Date: 2022-11-12 13:38:53
- Modify Date: 2024-01-10 01:11:38
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PI3KC2α-IN-3 is a potent and highly selective PI3KC2α inhibitor (IC50: 126 nM). PI3KC2α-IN-3 interacts with the ATP-binding site of PI3KC2α. PI3KC2α-IN-3 impairs endocytic membrane dynamics and membrane remodeling. PI3KC2α-IN-3 can be used in the research of thrombosis, diabetes and cancers[1].
| Name | PI3KC2α-IN-3 |
|---|
| Description | PI3KC2α-IN-3 is a potent and highly selective PI3KC2α inhibitor (IC50: 126 nM). PI3KC2α-IN-3 interacts with the ATP-binding site of PI3KC2α. PI3KC2α-IN-3 impairs endocytic membrane dynamics and membrane remodeling. PI3KC2α-IN-3 can be used in the research of thrombosis, diabetes and cancers[1]. |
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| Related Catalog | |
| Target |
PI3KC2α:126 nM (IC50) PI3KC2β:>10 μM (IC50) PI3KC2γ:>10 μM (IC50) |
| In Vitro | PI3KC2α-IN-3 (PITCOIN3, 30 nM-1 mM, HEK293T cell lysates) is highly selective in targeting PI3KC2α but no other human kinases (Kinobead profiling assay)[1]. PI3KC2α-IN-3 (100 μM, 20 h) shows no detectable cytotoxicity in HeLa cells[1]. PI3KC2α-IN-3 (6 h) blocks plasma membrane tubulation induced by eGFP–SNX9 in HeLa cells (EC50: 4.6 μM)[1]. PI3KC2α-IN-3 (20 μM, 6 h) results in impaired clathrin-mediated endocytosis of transferrin in Cos7 cells[1]. PI3KC2α-IN-3 (20 μM, 6 h) inhibits endosomal PI(3)P synthesis[1]. PI3KC2α-IN-3 (20 μM, 6 h) impairs platelet membrane and thrombus formation in mouse resting platelets[1]. Cell Viability Assay[1] Cell Line: Cos7 cells Concentration: 20 μM Incubation Time: 6 h Result: Reduced endosomal PI(3)P, and reduced endosomal membrane recruitment of the PI(3)P-binding effector early endosomal antigen 1 (EEA1). |
| Molecular Formula | C26H23N7O4S3 |
|---|---|
| Molecular Weight | 593.70 |