1360243-08-8
1360243-08-8 structure
- Name: LabMol-301
- Chemical Name: LabMol-301
- CAS Number: 1360243-08-8
- Molecular Formula: C18H16N6
- Molecular Weight: 316.36
- Catalog: Research Areas Infection
- Create Date: 2022-12-05 10:37:17
- Modify Date: 2024-04-06 16:21:50
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LabMol-301 inhibits both NS5 RdRp and NS2B-NS3pro activity (IC50: 0.8 and 7.4 μM, respectively). LabMol-301 has a cytoprotective effect and prevents Zika virus (ZIKV)-induced cell death[1].
| Name | LabMol-301 |
|---|
| Description | LabMol-301 inhibits both NS5 RdRp and NS2B-NS3pro activity (IC50: 0.8 and 7.4 μM, respectively). LabMol-301 has a cytoprotective effect and prevents Zika virus (ZIKV)-induced cell death[1]. |
|---|---|
| Related Catalog | |
| Target |
NS5 RdRp, NS2B-NS3pro[1] |
| In Vitro | LabMol-301 (20 μM) shows 99% inhibition rate of NS5 RdRp activity[1]. LabMol-301 (10 μM) inhibits more than 80% of the NS2B-NS3pro protease activity[1]. LabMol-301 interacts with ZIKV NS2B-NS3pro at the allosteric site relied on a highly hydrophobic complementarity between the molecule’s surfaces and the protein[1]. LabMol-301 is able to protect GSC387 cell from cell death induced by ZIKV (EC50: 6.68 μM)[1]. |
| Molecular Formula | C18H16N6 |
|---|---|
| Molecular Weight | 316.36 |