2437210-79-0

2437210-79-0 structure

2437210-79-0 structure

Name: Bafisontamab
Chemical Name: Bafisontamab
CAS Number: 2437210-79-0
Molecular Formula:
Molecular Weight:
Catalog: Signaling Pathways JAK/STAT Signaling EGFR
Create Date: 2023-02-07 16:43:53
Modify Date: 2024-04-05 19:48:00
Bafisontamab (EMB-01) is a bispecific antibody targeting EGFR and cMET with antitumor activity[1].

Name	Bafisontamab

Description	Bafisontamab (EMB-01) is a bispecific antibody targeting EGFR and cMET with antitumor activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Met/HGFR
Target	EGFR c-Met
In Vivo	Bafisontamab (EMB-01) 在 PDX 和 CDX 肿瘤模型中诱导的抗肿瘤活性明显强于抗 EGFR 单抗或抗 cMet 单抗。Bafisontamab 在抗 EGFR mAb 耐药肿瘤模型中表现出显著的抗肿瘤活性[1]。
References	[1]. Ren F, et al. EMB-01: An innovative bispecific antibody targeting EGFR and cMet on tumor cells mediates a novel mechanism to improve anti-tumor efficacy. Cancer Research, 2020, 80(16_Supplement): 528-528.

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